Prediction and odds analysis for Lille vs Lyon at 22:15 on September 28, Round 6 of Ligue 1

Lille recently defeated SK Brann 2-1 in the Europa League on September 19, 2025. Prior to that, they lost 0-3 to Lens (September 14, 2025), won 2-1 against Toulouse (August 31, 2025), thrashed Lorient 7-1 (August 24, 2025), and beat Monaco 1-0 (August 17, 2025). Their last 5 games show uneven form (3 wins, 1 loss, 1 draw), scoring 12 goals and conceding 6. Under coach Bruno Genesio, Lille will depend on Olivier Giroud and Edon Zhegrova to leverage home advantage.

Lyon just beat Utrecht 1-0 in the Europa League on September 19, 2025. Before that, they won 1-0 against Angers (September 14, 2025), lost 1-3 to Rennes (August 31, 2025), won 1-0 against Marseille (August 24, 2025), and beat Metz 3-0 (August 17, 2025). Their recent 5 matches show impressive form (4 wins, 1 loss), scoring 6 goals and conceding 3. Led by coach Jorge Maciel, Lyon will rely on Corentin Tolisso and Georges Mikautadze to sustain their performance.

The two teams have met 5 times recently, with Lyon winning twice, drawing twice, and Lille winning once, averaging 2.0 goals per game. Lille has home advantage with a recent unbeaten streak, while Lyon features a strong defense. A balanced contest with a narrow victory for Lille is a reasonable expectation.

Squad status Lille vs Lyon

Lille: Alexsandro (muscle injury), Thomas Meunier (groin injury), Benjamin Andre (injured), Romain Perraud (ankle injury), Ousmane Toure (ACL injury), Tiago Santos (ACL injury), Marc-Aurele Caillard (elbow injury); Olivier Giroud (available).

Lyon: Remy Descamps (wrist injury), Ernest Nuamah (ACL injury), Orel Mangala (ACL injury), Abner Vinicius (injured), Tyler Morton (available).

Expected lineups Lille vs Lyon

Lille: Ozer - Mandi, Ngoy, Mbemba, Verdonk - Bentaleb, Bouaddi - Fernandez-Pardo, Haraldsson, Sahraoui - Giroud.

Lyon: Greif - Maitland-Niles, Mata, Niakhate, Tagliafico - Tessmann, Morton - Sulc, Tolisso, Fofana - Satriano.

Lille form

19/09/25: Lille 2-1 SK Brann (Europa League)

14/09/25: Lens 3-0 Lille (Ligue 1)

31/08/25: Lille 2-1 Toulouse (Ligue 1)

24/08/25: Lorient 1-7 Lille (Ligue 1)

17/08/25: Lille 1-0 Monaco (Ligue 1)

Lyon form

19/09/25: Utrecht 0-1 Lyon (Europa League)

14/09/25: Lyon 1-0 Angers (Ligue 1)

31/08/25: Rennes 3-1 Lyon (Ligue 1)

24/08/25: Lyon 1-0 Marseille (Ligue 1)

17/08/25: Lyon 3-0 Metz (Ligue 1)

Head-to-head record Lille vs Lyon

05/04/25: Lyon 2-1 Lille (Ligue 1)

01/11/24: Lille 1-1 Lyon (Ligue 1)

06/05/24: Lille 3-4 Lyon (Ligue 1)

03/05/24: Lille 0-0 Lyon (Ligue 1)

07/02/24: Lyon 2-1 Lille (France Cup)

Prediction for Lille vs Lyon

With home advantage and the ability to score late, Lille could overcome Lyon to end their unbeaten streak. Although Lyon has a solid defense, recent head-to-head matches at Stade Pierre-Mauroy favor Lille. An exciting match with a narrow win for Lille is a likely outcome.

Predicted score: Lille 1-0 Lyon